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Optical Tomography and Spectroscopy

24 April 2022 – 27 April 2022 The Westin Fort Lauderdale Beach Resort, Fort Lauderdale, Florida United States

The topical will also include a specific focus on diagnostic and treatment-monitoring capabilities derived from probing tissues at the macroscopic level, as well as the development of portable and low-cost instrumentation.

Example topics central to this meeting are novel instrumentation, data analysis algorithms, pre-clinical and clinical applications highlighting the validation and applicability of novel methods and concepts. This meeting is unique in the sense that it brings together researchers working at all levels of this multidisciplinary effort and has historically provided the ecosystem feeding other more specialized areas and applications.


  1. Diffuse Optics (DOT/DOS, DCT/DCS)
    Covering all salient aspects ranging from algorithms and devices to pre-clinical and clinical applications.
  2. Laser Speckle Imaging
    Broadly, this area covers the use of laser speckles and their statistics for biomedical imaging and monitoring.
  3. Photoacoustic Tomography and Spectroscopy
    Covering all salient aspects ranging from algorithms and devices to pre-clinical and clinical applications.
  4. Raman Spectroscopy & Fluorescence Imaging
    These emerging new areas are represented at all levels from the physical basis to novel new devices to pre-clinical and clinical applications.
  5. The Future
    Novel technological developments for pre-clinical and clinical applications covering a wide range of methods.



  • Jana Kainerstorfer, Carnegie Mellon Univ., USA, General Chair
  • Amir Rosenthal, Technion, Israel, General Chair
  • Gemma Bale, UCL, UK, Program Chair
  • Chulhong Kim, Pohang University of Science and Technology, Korea, Program Chair
  • Audrey Bowden, Vanderbilt UniversityUnited States
    User-centric Hardware and Software Development for Low-cost Naturalistic Neuroimaging Using fNIRS
  • Sabrina Brigadoi, Università degli Studi di PadovaItaly
    The BabyGlucoLight Project: Understanding the Impact of Neonatal Glycemic Control on Brain Hemodynamics and Developmental Outcome in Very Preterm Neonates
  • Mamadou Diop, Lawson Health Research InstituteCanada
    Hyperspectral Time-Resolved Near Infrared Spectroscopy
  • James Guggenheim, University of BirminghamUnited Kingdom
    Enhancing Photoacoustic Imaging with Wavefront Shaping and Optical Ultrasound Sensors
  • Puxiang Lai, The Hong Kong Polytechnic UniversityHong Kong
    Photoacoustic Tomography and Wavefront Shaping: High-resolution Optical Imaging and Focusing at Depths in Biological Tissue
  • Chris McKnight, University of St AndrewsUnited Kingdom
    Near-infrared Spectroscopy on Animals
  • David Miller, Dynamic Light IncUnited States
    Laser Speckle Contrast Imaging for Intraoperative Blood Flow Visualization During Neurosurgery
  • Sara Mosca, UKRI Research EnglandUnited Kingdom
    Spatially Offset Raman Spectroscopy for Estimating the Depth of Inclusion in Diffusely Scattering Samples
  • Thao Pham, Boston UniversityUnited States
    Depth-Resolved Frequency-Domain Diffuse Optical Augmented Reality for Breast Cancer Monitoring
  • Shy Shoham, New York UniversityUnited States
    Optoacoustic Imaging of the Brain
  • Graham Spicer, University of CambridgeUnited Kingdom
    Spectral Endoscopy Enhances Contrast for Cancer Detection
  • Tanja Tarvainen, Itä-Suomen YliopistoFinland
    Modelling and Inverse Problem in Diffuse Optical Tomography and Quantitative Photoacoustic Tomography
  • Liangzhong Xiang, University of California IrvineUnited States
    X-ray Induced Acoustic Computed Tomography (XACT)



  • Michal Balberg, Holon Institute of Technology, Israel
  • Stefan Carp, Massachusetts General Hospital, United States
  • Regine Choe, University of Rochester, United States
  • Laura Di Sieno, Politecnico di Milano, Italy
  • Turgut Durduran, ICFO -Institut de Ciencies Fotoniques, Spain
  • Sergio Fantini, Tufts University, United States
  • Parsin Haji Reza, University of Waterloo, Canada
  • Tiffany Ko, Children's Hospital of Philadelphia, United States
  • Frederic Lange, University College London, United Kingdom
  • Chengbo Liu, Chinese Academy of Sciences, China
  • Srivalleesha Mallidi, Tufts University, United States
  • Farouk Nouizi, University of California Irvine, United States
  • Ashwin Parthasarathy, University of South Florida, United States
  • Paola Pinti, Birkbeck University of London, United Kingdom
  • Manojit Pramanik, Nanyang Technological University, Singapore
  • Narasimhan Rajaram, University of Arkansas, United States
  • Dustin Shipp, Utah Valley University, United States
  • Tanja Tarvainen, Itä-Suomen Yliopisto, Finland
  • Xueding Wang, University of Michigan, United States
  • Jun Xia, University at Buffalo, United States
  • Meryem Yucel, Boston University, United States


Plenary Session

Laura Marcu

University of California, Davis, USA

Bringing Cancer to Light in the Operating Room

This presentation concerns the development for clinically-compatible multispectral fluorescence lifetime imaging (FLIM) techniques and applications in surgical oncology. We will show FLIM’s potential for real-time intraoperative delineation of brain tumors and head-and-neck cancer during robotic surgery.

About the Speaker

Laura Marcu is Professor of Biomedical Engineering and Neurological Surgery at the University of California at Davis. She received her Ph.D. in biomedical engineering (1998) from the University of Southern California, Los Angeles. Since 2007, she has served also as co-director of the Comprehensive Cancer Center - Biomedical Technology Program at the UC Davis Medical Center. Her research interest is in the area of biomedical optics, with a particular focus on research for the development of label-free optical spectroscopy and imaging techniques for tissue diagnostics and image-guided interventions. Area of applications include surgical oncology, intravascular cardiovascular diagnostics, and regenerative medicine. She is an elected Fellow of AAAS, AIMBE, BMES, Optica, SPIE and NAI.

Wolfgang Drexler

Medical University Vienna, Austria

OCT in its 30's

After three decades, more than 75,000 publications and numerous companies being involved in its commercialization, this talk focuses on disruptive forward-looking innovations and key-technologies to further boost OCT performance enabling significantly enhanced medical diagnosis.

About the Speaker

Wolfgang Drexler, PhD, is a Professor of Medical Physics and the Head of the Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna, Vienna, Austria. He spent 2 years at the Massachusetts Institute of Technology, Cambridge, MA, USA. Prior to his current position, Dr. Drexler was a Professor of Biomedical Imaging at Cardiff University, Wales, UK. Dr. Drexler’s main research area is the establishment of a novel generation of optical imaging platforms with the potential to revolutionise fundamental biological research as well as medical diagnosis. Dr. Drexler has authored >190 peer-reviewed publications and >600 conference proceedings or abstracts. He is or has previously held positions as editor or co-editor of 12 books, including 2 editions of Optical Coherence Tomography: Technology and Applications. In addition, he has given >250 invited or keynote presentations since 2000 and accomplished € 16 million research grant income since 2000.

Daniel Razansky

ETH Zürich, Switzerland

Citius, altius, fortius – boosting speed, resolution, and depth in fluorescence and optoacoustic imaging

The talk focuses on the latest additions to the arsenal of fluorescence and optoacoustic techniques to enable noninvasive deep tissue imaging of rapid biological dynamics at multiple scales, from single cells to whole organisms.

About the Speaker

Daniel Razansky is Full Professor of Biomedical Imaging with double appointment at the Faculty of Medicine, University of Zurich and the Department of Information Technologies and Electrical Engineering of ETH Zurich, where he also serves as Director of the joint Preclinical Imaging Center. He earned PhD in Biomedical Engineering (2006) and MSc in Electrical Engineering (2001) from the Technion - Israel Institute of Technology and did postdoctoral research at the Center for Molecular Imaging Research of the Harvard Medical School in Boston. Prior to moving to Zurich in 2019, he was Professor of Molecular Imaging Engineering at the Technical University of Munich and Helmholtz Center Munich. His Lab pioneered a number of imaging technologies for pre-​clinical research and clinical diagnostics successfully commercialized worldwide, among them the multi-​spectral optoacoustic tomography (MSOT) and hybrid optoacoustic ultrasound (OPUS). Razansky’s research has been recognized by the German Innovation Prize and multiple awards from the ERC, NIH, SNF, DFG and HFSP. He is a Founding Editor of the Photoacoustics journal and serves on Editorial Boards of a number of journals published by Springer-​Nature, Elsevier, IEEE and AAPM. He is also an elected Council Member of the European Society for Molecular Imaging (ESMI), serves on the IEEE Technical Committee on Biomedical Imaging and Image Processing and has chaired numerous international conferences of the Optica (formerly OSA), WMIS, IEEE, ESMI and IFMBE. He is also an elected Fellow of the Optica (formerly OSA) and SPIE.

Anita Mahadevan-Jansen

Vanderbilt University, USA

Near infrared autofluorescence and other label free optical techniques for intraoperative guidance of endocrine surgery

 In this presentation, the development of label free spectroscopy and imaging methods including near infrared autofluorescence for the identification of the parathyroid gland and evaluating its perfusion state during thyroidectomies and parathyroidectomies will be presented. We will also discuss other ways in which optical spectroscopy and imaging can help the endocrine surgeon in patient care.  

About the Speaker

Anita Mahadevan-Jansen is a Professor of Biomedical Engineering and holds the Orrin H. Ingram Chair in Biomedical Engineering at Vanderbilt University. Her research considers the development of optical techniques for clinical diagnosis and surgical guidance, particularly using Raman and fluorescence spectroscopy. She serves on the Board of Directors of SPIE, and is a Fellow of SPIE, Optica, Society for Applied Spectroscopy, and the American Society for Lasers in Medicine and Surgery. She is currently serving as SPIE's President in 2022.


Special Events

Women of Biophotonics Meet & Greet

Saturday, 23 April 19:00 – 20:00

Please join Chairs Christine P. Hendon, Rainer A. Leitgeb and other members of the Biophotonics Congress committee for an informal networking event bringing together the women in biomedical optics. The program's goal is to provide an opportunity to meet other women in the field and discuss challenges and opportunities for women in biophotonics. All are welcome, regardless of gender, so please join us to meet others attending this cutting-edge conference and share your ideas on helping ensure our community and this meeting is as welcoming and inclusive as possible.

The Physicians' Perspective: A Joint MHA and Translational Session

Sunday, 24 April 13:30 – 15:30

13:30-14:00: Optical Skin Biopsy with Line-field Confocal Optical Coherence Tomography (LC-OCT), Arnaud Dubois, Damae Medical, France
14:00-15:30: Panel Discussion: Clinicians' Perspective on Optical Imaging in Patient Care

We will explore the challenges and opportunities for direct clinical impact of innovations in microscopy and related technologies. Panelists are all practicing clinicians who routinely use imaging to directly provide patient care. In this lively and interactive live discussion, we will explore exciting and sometimes controversial topics off-the-record, including:

  • artifical intelligence: hype vs true clinical game-changer
  • barriers to clinical uptake of novel microscopies
  • best practices to engage clinicians and patients with new technologies
  • commonly missed critical factors for clinical work flow
  • real world medicolegal and ethical concerns

Please send suggestions for topics or questions for the panel to Suggestions from trainees and junior colleagues are particularly encouraged.

Eric Tkaczyk, MD, PhD, Vanderbilt University Medical Center, USA
Milind Rajadhyaksha, PhD, Memorial Sloan Kettering Cancer Center, USA

Richard Levenson, MD, UC Davis Health, USA
Vic Neel, MD, PhD, Massachusetts General Hospital, USA
Harold Rabinovitz, MD, Skin and Cancer Associates - Plantation, USA
Gennady Rubinstein, MD, Dermatology & Laser Centre, USA
Eric Yang, MD, PhD, Stanford University School of Medicine, USA

Endometriosis Innovation Challenge Finalist Demonstrations

Tuesday, 26 April 09:30 – 10:00

Innovation Finalists Mária Pilar Urizar, IO-CSIC, Spain and Mahima Sharma, IIT Madras, India will present their proposals for the Endometriosis Challenge. Attendees will vote on the winner through the conference app.