Clinical and Translational Biophotonics

20 April 2020 – 23 April 2020 OSA Virtual Event - Eastern Time (US & Canada) (UTC - 05:00)

The meeting spans clinical diagnostic, surgical guidance and therapeutic approaches that use light, with applications ranging from cancer to ophthalmology and global health. It will also include technologies for in-vivo laboratory disease research including contrast agent development and intravital microscopy in animal models.

Presented work will include reports of novel and developing technologies for clinical applications, demonstrations of clinical applications and clinical trial results, with presenters encouraged to share their experiences relating to the challenges of clinical translation. Events will include panel discussions and networking forums to develop skills and expertise for clinical translation, FDA and regulatory hurdles and fundraising.


Topics

  1. Preclinical disease research: techniques and applications
    • Molecular contrast agents, probes and reporters
    • Imaging methods for small animal models of cancer and other diseases
    • Optical imaging of the cancer microenvironment, processes and pathways
    • Targeted molecular imaging of cancer, and quantitative validation methods
    • Bioluminescence techniques and applications to disease research
    • Photoacoustics in disease research
    • Intravital microscopy for pre-clinical disease research
  2. Intravital microscopy for clinical applications
    • OCT techniques and applications in humans
    • Endomicroscopy
    • FLIM for clinical applications
    • Multimodal microscopy for clinical applications
    • Raman microscopy for clinical applications
    • Micro-elastograpy and optical biomechanics
    • Skin imaging techniques and applications
  3. Clinical spectroscopy
    • Optical properties of disease
    • Intravital spectroscopy for clinical applications
    • Hyperspectral imaging techniques and applications in medicine
    • Modeling of light propagation and optical properties
  4. Intrasurgical imaging
    • Optical approaches for surgical guidance
    • Intravital optical biopsy
    • Perfusion evaluation
    • Combined contrast agent / imaging approaches
    • Dynamic contrast
    • Applications in neurological surgery
    • Applications in cancer resection
  5. Non-invasive optical imaging for disease applications
    • Tomography approaches for clinical applications
    • Multi-modal imaging (e.g. combined with x-ray, MRI, ultrasound)
    • Photoacoustic techniques and applications in the clinic
  6. Optical therapeutics / theranostics
    • PDT, agents, techniques and applications
    • Thermal ablation
    • Agents for optical therapy
    • Laser surgery
    • Optical dosimetry
  7. Clinical translation: Biophotonics in the clinic and beyond
    • Global health
    • Applications in women’s health
    • Applications in ophthalmology
    • Applications in dermatology
    • New contrast agents in the clinic
    • Testing and evaluation of new clinical modalities
    • Challenges and trajectories of clinical translation

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Speakers

  • Stefan Andersson Engels, Tyndall National InstituteIreland
    Towards Transdermal Clinical Assessment of Gas Content in Lungs of Neonates – Measurements and Computer Simulations Based on Well-characterized Anthropomorphics Models
  • Christine Hendon, Columbia UniversityUnited States
    Monitoring and Guidance of Ablation Therapy with Optic
  • Cristina Kurachi, University of São PauloBrazil
    Widefield FLIm and Photodynamic Therapy for Skin Cancer - Clinical Trial Results
  • Frederic Leblond, Polytechnique MontréalCanada
    Multimodal Optical Spectroscopy to Detect Endogenous Tissue Contrast in Urological Oncology
  • Stephen Morgan, University of NottinghamUnited Kingdom
    Development and Translation of intra-Tracheal Multiplexed Sensing Endotracheal Tubes (iTraXS)
  • Seemantini Nadkarni, Harvard Medical SchoolUnited States
    Optical Micromechanics Using Laser Speckle Techniques
  • G.J. Puppels, Erasmus University Medical CenterNetherlands
    Intraoperative Raman Spectroscopic Assessment of Resection Margins in Oral Cancer Surgery
  • Milind Rajadhyaksha, Memorial Sloan Kettering Cancer CenterUnited States
    The Evolving Role of Confocal Microscopy Combined with Optical Coherence Tomography to Guide Mohs Surgery: Early Adoption at the Bedside
  • Darren Roblyer, Boston UniversityUnited States
    Tracking Breast Cancer Therapies with Handheld and Wearable Diffuse Optics
  • Guillermo Tearney, Wellman Center for PhotomedicineUnited States
    Title to be announced.
  • Quing Zhu, Washington University in St LouisUnited States
    Dual-modality Photoacoustic and Ultrasound Imaging for Assessing Treatment Response in Colorectal Cancer

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Committee

  • Kate Bechtel, Triple Ring Technologies, United StatesChair
  • Laura Marcu, University of California Davis, United StatesChair
  • Daniel Elson, Imperial College London, United KingdomProgram Chair
  • James Tunnell, University of Texas at Austin, United StatesProgram Chair
  • Irving Bigio, Boston University, United States
  • Sarah Bohndiek, University of Cambridge, United Kingdom
  • Stephen Boppart, Univ of Illinois at Urbana-Champaign, United States
  • Brett Bouma, Massachusetts General Hospital, United States
  • Anuradha Godavarty, Florida International University, United States
  • Ewa Goldys, University of New South Wales, Australia
  • Ioan Notingher, University of Nottingham, United Kingdom
  • Juergen Popp, Friedrich-Schiller-Universität Jena, Germany
  • Narasimhan Rajaram, University of Arkansas, United States
  • Jessica Ramella-Roman, Florida International University, United States
  • Daniel Razansky, University and ETH Zurich, Switzerland
  • Ronald Sroka, Ludwig-Maximillians-Universität Munchen, Germany
  • Lei Su, Queen Mary University of London, United Kingdom
  • Adam Wax, Duke University, United States
  • Brian Wong, University of California Irvine, United States

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Plenary Session

Steven LeBoeuf

Valencell, Inc, USA

Cuff-like Accuracy in Blood Pressure Monitoring via Wearable Photoplethysmography and Machine Learning

In this study, a machine learning model was developed to predict blood pressure(BP) based on optical and inertial sensor data collected from a commercially available photoplethysmography (PPG) sensor module embedded within a wearable device.

About the Speaker

Inventor of more than 80 granted patents and more than 100 patents pending in the field of wearable biomedical sensing, Steven LeBoeuf is one of the foundational innovators in wearable PPG sensors that are now embedded in millions of wearables on the market today. Before founding Valencell in 2006, Dr. LeBoeuf pioneered innovations in solid state materials, multiwavelength optoelectronic devices, high-power electronics, nanostructured materials and devices, and biochemical sensor systems while serving as a Senior Scientist and Biosensor Project Lead for General Electric. LeBoeuf has developed dozens of strategic partnerships with industry leading consumer technology brands, medical professionals, research institutions, medical device manufacturers, health and fitness companies, and start-ups. One of the most broadly quoted scientists and entrepreneurs in the field of wearable PPG sensing, LeBoeuf has served as a speaker in 50+ events around the world and is routinely interviewed by journalists, industry analysts, venture capitalists, and academic researchers. As a founding pioneer in modern wearables, LeBoeuf has managed Valencell’s foundational patent portfolio, which has been licensed to dozens of companies around the world and implemented in 40+ wearable devices, ranging from earbuds, hearing aids, wristbands, legbands, smartwatches, virtual reality systems, headbands and more. LeBoeuf holds a PhD in Electrical Engineering from North Carolina State University and BS degree in Electrical Engineering and Mathematics at Louisiana Tech University.

Catharine Young

SHEPHERD Foundation, USA

The Optics of a Changing Scientific Landscape

Based on the current pandemic, society will be forced to rethink how we operate on many levels and academia is no different. From graduate education, to policy reform to mentoring we now face an inflection point.

About the Speaker

Originally from South Africa, Dr. Catharine Young holds a doctorate degree in Biomedical Sciences and previously served as the Senior Director of Science Policy for the Biden Cancer Initiative. Here she fostered discussion and collaboration within the biotech, technology, science, and academic fields to drive innovation solutions and breakthroughs against cancer. Prior to this position, Catharine served as the Senior Science and Innovation Policy Advisor and Head of the DC team for the Foreign Ministry of the UK. Based at the British Embassy, Catharine influenced science and innovation policies of both the UK and US governments, industry, and academia. Following her Postdoctoral training at Cornell University in Biomedical Engineering, Catharine was selected as a AAAS Science and Technology Policy Fellow in the Office of the Assistant Secretary of Defense for Nuclear, Chemical, and Biological Defense Programs. Here she led international engagements on eliminating biological weapons, improving biosafety and biosecurity, and assisting in the DoD's response to the Ebola outbreak in Western Africa. Catharine also co-founded Blueprint International, a non-profit dedicated to providing novel technological solutions to some of the world’s most pressing social issues. Catharine is the Executive Director of the SHEPHERD Foundation. Recent awards include being selected as a TED Fellow, Alexandria 40 Under 40 and Social Enablers top 100 most inspiring social entrepreneurs. Catharine is an advocate for women in STEM and has been a contributor to major social and media networks including TED-Ed, the Guardian and the UK Science and Innovation Network.

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