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Optical Manipulation and Its Applications

14 April 2019 – 17 April 2019 Loews Ventana Canyon Resort, Tucson, Arizona United States

This meeting covers the whole range of optical manipulation technologies currently being developed for studies in biophysics, single molecule, single cell and tissue level analysis, optical manipulation of chemical processes in organisms, lab-on-a-chip development, optomechanical cooling, environmental monitoring and theoretical underpinnings. Technologies to be considered include optical tweezers and associated techniques, photo activated materials, optogenetics, light-activated drugs and probes, and microfluidics. In this way, we will try and capture synergies between different optical manipulation technologies with a view to encouraging discussion between different user groups and the development of new hybrid techniques.


1. Optical Manipulation in Biophysics and Biomedicine

  • Single molecule biophysics
  • Cellular mechanics and mechanotransduction
  • Cellular adhesion
  • Laser cellular surgery and photoporation
  • Light activated drugs and probes
  • Cell stretching
  • Optogenetics
  • Optical biomodulation

2. Optical Manipulation Fundamentals

  • Holographic optical tweezers and beam shaping, adaptive optics techniques
  • Particle dynamics
  • Opto-mechanical cooling
  • Microrheology
  • High force optical tweezers
  • Photophoresis
  • Optical trap modelling and theoretical underpinnings
  • Nanoparticle manipulation
  • Plasmonic manipulation
  • Integrated and near-field optical trapping

3. Optical Manipulation Applications

  • Non-equilibrium statistical mechanics
  • Nanoscale & quantum sensing
  • Environmental sensing and aerosol analysis
  • Optofluidics/microfluidics
  • Integration with spectroscopic techniques
  • Photo activated molecules and materials

4. Alternative Manipulation Techniques

  • Magnetic tweezers
  • Electrical manipulation: Electrodynamic balance, dielectrophoresis, etc
  • Acoustic manipulation and trapping
  • Microfluidic manipulation
  • Optoelectronic Tweezers
  • AFM applied to techniques studied by optical manipulation



  • Alexandra Artusio-Glimpse, National Inst of Standards & TechnologyUnited States 
    Momentum and a new traceability path for optical power
  • Alejandro Arzola, UNAM CCADETMexico 
    Optical Ratchets: Controlling Transport far from Equilibrium
  • Oto Brzobohaty, ISI of the CAS, v.v.i.Czech Republic 
    Tunable soft-matter optofluidic waveguides assembled by light
  • Marco Capitanio, LENSItaly 
    To be Determined
  • Cornelia Denz, Westfaelische Wilhelms Univ MunsterGermany 
    Optical Trapping and Optomechanically-assisted Assembly of Non-Spherical Nanocontainers
  • Kishan Dholakia, University of St AndrewsUnited Kingdom 
    Trapping in a Material World
  • Itia Favre-Bulle, University of QueenslandAustralia 
    Optical Trapping in Zebrafish for Neuroscience
  • Jochen Guck, University of CambridgeGermany 
    Dual-beam laser traps – the other optical trap Arthur Ashkin invented
  • Maria Iati, Istituto per i Processi Chimico-FisiciItaly 
    Optical Trapping of Hybrid Nanostructures
  • Sabine Klapp, Technische Universität BerlinGermany 
    Manipulation of colloidal transport by time-delayed feedback control
  • Moritz Kreysing, MPI fur Molekulare Biomedizin 
    Optical induction of hydrodynamic flows in cells and embryos
  • Masud Mansuripur, University of ArizonaUnited States 
    Self-field, radiated energy, and radiated linear momentum of an accelerated point charge
  • Nicolas Mauranyapin, University of Queensland 
    Biosensing at the Quantum Noise Limite
  • Kang-Kuen Ni, Harvard University 
    Building single molecules atom-by-atom in optical tweezers
  • Pedro Quinto-Su, ICN-UNAMMexico 
    Microparticle transport across optical potentials: noisy ratchets and cavitation bubbles
  • Basudev Roy, Eberhard-Karls-Universität TubingenIndia 
    Determination of twisting of kinesin molecules during stepping
  • Quan Wang, Princeton UniversityUnited States 
    Single-molecule measurements on individual biomolecules held in an electrokinetic trap
  • Ming Wu, University of California BerkeleyUnited States 
    Optoelectronic Tweezers – A New Optofluidic Platform for Single Cell Biology
  • Kai Zhang, Univ of Illinois at Urbana-ChampaignUnited States 
    Reversible Optogenetic Control of Growth Factor Signaling During Cell Differentiation and Vertebrate Embryonic Development
  • Yuebing Zheng, University of Texas at AustinUnited States 
    Optothermal manipulations of colloidal particles and living cells



Peter Pauzauskie, University of Washington , Chair
Giovanni Volpe, Goteborgs Universitet, Sweden , Chair
Frank Cichos, Univ Leipzig, Germany , Program Chair
Lene Oddershede, The Niels Bohr Institute, Denmark , Program Chair
Haw Yang, Princeton University, United States , Program Chair

Timo Betz, University of Muenster, Germany
Agnese Callegari, Bilkent University, Turkey
Reuven Gordon, University of Victoria, Canada
Heiner Linke, Lunds Universitet, Sweden
Onofrio Marago, CNR-IPCF, Italy
Steven Neale, University of Glasgow, UK
Antonio Neves, Universidade Federal do ABC, Brazil
Sile Nic Chormaic, Okinawa Institute of Science & Technology, Japan
Peter Reece, University of New South Wales, Australia
Halina Rubinsztein-Dunlop, University of Queensland, Australia
Iva Tolic, Ruđer Bošković Institute, Croatia
Karen Volke-Sepulveda, Universidad Nacional Autonoma de Mexico, Mexico
Pavel Zemanek, Institute of Scientific Instruments ASCR, Czech Republic
Chenglong Zhao, University of Dayton, USA


Plenary Session

Valentina Emiliani

Vision Institute Paris, France

Toward Circuit Optogenetics

Valentina will present how recent joint progress in light delivering approaches, opsins engineering and laser sources development have brought the field of optogenetics into a new phase that we can name ‘circuit optogenetics’, where neural circuits can be optically interrogated with milli-second temporal precision and single-cell resolution.

About the Speaker

Valentina Emiliani joined the Max Born Institute after having obtained her PhD in Physics in Rome in 1998.  She investigate carrier transport in quantum wire by near field optical microscopy (SNOM). In 2002 she moved at the European Laboratory for Nonlinear Spectroscopy to lead a research group focused on the investigation of light propagation in disordered structure by SNOM. In 2002 she moved to Paris at the Institute Jacques Monod in Paris. Her interest was to study the role of mechanical forces on the establishment of cell polarity by optical tweezers. In 2005 she was awarded with the European Young Investigator grant and formed the “Wave front engineering microscopy” group at Paris Descartes University, pioneering the use of wave front shaping for neuroscience. Valentina became research director in 2011 and Director of the Neurophotonics laboratory in 2014.

In 2018, she moved her group at the Vision Institute in Paris where she has also taken the head of the photonics department. In 2015 she obtained the Prix “Coups d’élan pour la recherche française” from the Bettencourt-Shueller foundation and in 2017 the Axa chair  “Investigation of visual circuits by optical wave front shaping “.

Aydogan Ozcan

California NanoSystems Institute UCLA, USA

Deep Learning-enabled Computational Microscopy and Sensing

Deep learning is a class of machine learning techniques that uses multi-layered artificial neural networks for automated analysis of signals or data. The name comes from the general structure of deep neural networks, which consist of several layers of artificial neurons, each performing a nonlinear operation, stacked over each other. Beyond its main stream applications such as the recognition and labeling of specific features in images, deep learning holds numerous opportunities for revolutionizing image formation, reconstruction and sensing fields. In this presentation, I will provide an overview of some of our recent work on the use of deep neural networks in advancing computational microscopy and sensing systems, also covering their biomedical applications.

About the Speaker

Aydogan Ozcan is the Chancellor’s Professor at UCLA and an HHMI Professor with the Howard Hughes Medical Institute, leading the Bio- and Nano-Photonics Laboratory at UCLA and is also the Associate Director of the California NanoSystems Institute. Ozcan holds 38 issued patents and >20 pending patent applications and is also the author of one book and the co-author of >500 peer-reviewed publications in major scientific journals and conferences.

Ozcan is the founder and a member of the Board of Directors of Lucendi Inc. and Holomic/Cellmic LLC, which was named a Technology Pioneer by The World Economic Forum in 2015. Dr. Ozcan is a Fellow of the International Photonics Society (SPIE), The Optical Society (OSA), the American Institute for Medical and Biological Engineering (AIMBE), the Institute of Electrical and Electronics Engineers (IEEE), the Royal Society of Chemistry (RSC), and the Guggenheim Foundation, and has received major awards including the Presidential Early Career Award for Scientists and Engineers, International Commission for Optics Prize, Biophotonics Technology Innovator Award, Rahmi M. Koc Science Medal, International Photonics Society Early Career Achievement Award, Army Young Investigator Award, NSF CAREER Award, NIH Director’s New Innovator Award, Navy Young Investigator Award, IEEE Photonics Society Young Investigator Award and Distinguished Lecturer Award, National Geographic Emerging Explorer Award, National Academy of Engineering The Grainger Foundation Frontiers of Engineering Award and MIT’s TR35 Award for his seminal contributions to computational imaging, sensing and diagnostics.


Special Events

Hot Topic Discussions

Monday, 15 April, 13:00-13:45
Join your colleagues for informal discussions on a selection of current hot topics . Round tables will be set on the back patio and a different topic will be featured at each table. Topics to be discussed include, Deep Learning for Quantitative Imaging Analysis, Artificial Intelligence in Optics and Photonics and Implicit Bias . You can also bring your own topic and host a table . Please note that lunch will not be provided . We recommend that you visit the hotel’s Visita Barista or Bill’s Grill for lunch and then come on over with it.

Student & Early Career Professional Development & Networking Lunch and Learn

Monday, 15 April, 12:30–14:00
This program will provide a unique opportunity for students and early career professionals, who are close to finishing or who have recently finished their doctorate degree, to interact with experienced researchers. Key industry and academic leaders in the community will be matched for each student based on the student's preference or similarity of research interests. Students interested in all career paths – from those seeking an academic position, to those wishing to start a technology business, to those interested government/public service, to those looking to translate their benchwork skills to product development – are encouraged to apply.  Students will have an opportunity to discuss their ongoing research and career plans with their mentor, while mentors will share their professional journey and provide useful tips to those who attend. Lunch will be provided.

This Workshop is complimentary for OSA Members and space is limited. Not all who apply will be able to attend due to space limitations and priority will be given to those who have most recently or are close to graduation. 

Hosted By: OSA Foundation

Congress Reception 

Monday, 15 April, 18:30–20:00
Join your fellow attendees for the Congress Reception. Enjoy western fare while dancing the night away in the hotel's Coyote Corral. One reception ticket is included in the Full Technical Registration Fee. Guest tickets may be purchased for US $50.

 Emerging Biomedical Applications of Nonlinear Optics

Tuesday, 16 April; 12:30-14:00
Join the OSA Nonlinear Optics Technical Group for this special event exploring potential applications for nonlinear optics within the field of biomedical optics. Our speakers will give short five-minute talks on their research, which is at the intersection of nonlinear optics and biomedical engineering, followed by a moderated question and answer session. This technical group event will also provide an opportunity for you to network with others who share an interest in this area. 

Hosted By: OSA Nonlinear Optics technical Group

A Celebration of the Nobel Prize Winning Work of Arthur Ashkin

Tuesday, 16 April, 17:30–19:30
Attendees are invited to join the OSA Optical Trapping and Manipulation in Molecular and Cellular Biology Technical group as they celebrate the pioneering work of Dr. Arthur Ashkin. The event will bring together members of the optical trapping community to recognize Dr. Ashkin for receiving the 2018 Nobel Prize in Physics and to discuss his work in this area. Dr. Gabe Spalding of Illinois Wesleyan University will give a brief presentation reflecting on Ashkin’s work, which will be followed by a networking reception bringing together researchers who share an interest in optical trapping and manipulation.

Hosted By: OSA Optical Trapping and Manipulation in Molecular and Cellular Biology Technical Group


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