Gentle Probes for 4D Physiology
Hosted By: Molecular Probes and Nanobio-optics Technical Group
15 June 2022 10:00 - 11:00
Eastern Time (US & Canada) (UTC -05:00)Modern fluorescence-imaging methods promise to unveil organelle dynamics in live cells.
Phototoxicity, however, has become a prevailing issue when boosted illumination applies. This webinar is being hosted by the Molecular Probes and Nanobio-Optics Technical Group. Zhixing Chen from Peking University will showcase how to engineer organic dyes with minimal phototoxicity with two examples on mitochondrial markers and insulin secretion markers. Resonating with the ongoing theme of reducing photodamage using optical approaches, these biocompatible probes promise to offer reliable spatial-temporal information in the era of 4D physiology.
Subject Matter Level: Intermediate - Assumes basic knowledge of the topic
What You Will Learn:
- Phototoxicity is a fundamental yet overlooked hurdle in the era of 4D physiology
- Phototoxicity can be alleviated not only by optical means but chemistry plays a big part
Who Should Attend:
- Researchers, engineers, and students in the biomedical optics field
About the Presenter: Zhixing Chen, Peking University
Dr. Zhixing Chen received his BS in chemical biology from Tsinghua University (2008) and PhD in chemistry from Columbia University (2014, With Profs. Virginia Cornish and Wei Min). Chen has additional trainings at Stanford University (Postdoc 2016-2018), Columbia University (Postdoc 2015) and Peking University (RA 2008-2009). Zhixing is a chemist with research experience spanning natural product synthesis, polymer chemistry, fluorescence and non-linear optical probes, bioconjugation chemistry and live cell imaging. Notable achievements include: Vibrational Palette -- isotopically edited alkyne and nitrile group for multiplexed Raman imaging, and Ladderene Unzipping -- using mechanical force to reconfigure polymer from an insulating material to a semiconductor. Zhixing's current focus is to develop new imaging tools with high biocompatibility to promote advanced bioimaging technologies.
