Implantable reconnectable fiber probes designed for this work provide a wavelength-multiplex forward-propagation channel for a spatially localized, dual-pathway excitation of genetically encoded fluorescence-protein sensors along with a back-propagation channel for the fluorescence return from optically driven fluorescence sensors. Dr. Zheltikov will show that the spectral analysis of the fiber-probe-collected fluorescence return provides means for a high-fidelity autofluorescence background subtraction, thus enhancing the sensitivity of real-time detection of stroke-induced reactive-oxygen transients and significantly reducing measurement uncertainties in in vivo acute-stroke studies as inherently statistical experiments operating with outcomes of multiply repeated measurements on large populations of individually variable animal stroke models.

Subject Matter Level: Intermediate - Assumes basic knowledge of the topic

What You Will Learn:

• Fiber-based biophotonic technologies
• Principles of fiber-optic detection of brain pathologies

About the Presenter: Aleksei Zheltikov, Texas A&M University

Aleksei Zheltikov received his PhD, as well as his Doctor of Science degree from M.V. Lomonosov Moscow State University in 1990 and 1999, respectively. He became a full professor at M.V. Lomonosov Moscow State University in 2000. Since 2010, he is a professor at Texas A&M University. His research is focused on ultrafast nonlinear optics and biophotonics. Author of more than 600 publications in peer-reviewed journals. The winner of the Russian Federation State Prize for young researchers (1997), Lamb Award for achievements in quantum electronics (2010), Shuvalov Prize for research at Moscow State University (2001), and Kurchatov Prize for achievements in neurophotonics (2014).